Th17 cytokines regulate profibrotic cytokines release by human eosinophils
نویسندگان
چکیده
منابع مشابه
Th17 cytokines regulate profibrotic cytokines release by human eosinophils
Rationale Asthma is a chronic inflammatory disorder of the lung airways that is associated with airway remodeling and hyperresponsiveness. One of the most critical structural changes that affect airway functionality is fibrotic tissue deposition within the airway wall. Eosinophils have been proposed in different studies to contribute to the production of several mediators and cytokines, includi...
متن کاملTh17 cytokines induce pro-fibrotic cytokines release from human eosinophils
BACKGROUND Subepithelial fibrosis is one of the most critical structural changes affecting bronchial airway function during asthma. Eosinophils have been shown to contribute to the production of pro-fibrotic cytokines, TGF-β and IL-11, however, the mechanism regulating this process is not fully understood. OBJECTIVE In this report, we investigated whether cytokines associated with inflammatio...
متن کاملMechanisims of asthma and allergic disease – 1092. Regulation of profibrotic cytokines release from human eosinophils by Th17 cytokines
Background Asthma is a chronic inflammatory disorder of the lung airways that is associated with airway remodeling and hyperresponsiveness. One of the most critical structural changes that affect airway functionality is fibrotic tissue deposition within the airway wall. Eosinophils have been proposed in different studies to contribute to the production of several mediators and cytokines, includ...
متن کاملBiology of TH17 Lymphocytes, their Cytokines and Role in Disease
T lymphocytes that are involved in cellular mediated immunity include two types known as TCD8+ (Cytotoxic T lymphocytes) and TCD4+ (helper T lymphocytes). TCD4+ has four main subtypes, including TH1, TH2, TH17, and Treg Lymphocytes.TH17 lymphocytes play a role in defense against microbes that TH1 and TH2 lymphocytes have not the ability to respond to them. The most important cytokines, which ar...
متن کاملInteracting cytokines regulate in vitro human megakaryocytopoiesis.
The effects of hematopoietic growth factors on in vitro human megakaryocytopoiesis were studied using a serum-depleted culture system. Both recombinant interleukin-3 (r-IL-3) and recombinant granulocyte-macrophage colony-stimulating factor (rGM-CSF) increased megakaryocyte (MK) colony formation (P less than .01) above that observed in baseline cultures. Recombinant interleukin-4 (rIL-4) and int...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Allergy, Asthma & Clinical Immunology
سال: 2012
ISSN: 1710-1492
DOI: 10.1186/1710-1492-8-s1-a2